Spurs will kick-off their 2021/22 Premier League campaign at home to reigning champions Manchester City.
They will then travel to Wolves and host newly promoted Watford before the September international break.
Tottenham will visit north London rivals Arsenal on September 25, with the reverse fixture coming on January 15.
Their Boxing Day fixture comes at home to Crystal Palace, before also visiting Southampton and Watford over the festive period.
They wrap up the season away at Championship winners Norwich.
? Our 2021/22 #PLFixtures have landed! pic.twitter.com/36Q4ynDz5R
— Tottenham Hotspur (@SpursOfficial) June 16, 2021
Many of Spurs' games are expected to be moved to Sundays due to their participation in the inaugural Europa Conference League.
Here is the full list of Tottenham's Premier League fixtures...
Tottenham Hotspur 2021/22 Premier League fixtures
Exact dates and kick-off times are subject to change depending on TV schedules.
Gameweek 1 - 14/08/2021 - Tottenham Hotspur v Manchester City
Gameweek 2 - 21/08/2021 - Wolverhampton v Tottenham Hotspur
Gameweek 3 - 28/08/2021 - Tottenham Hotspur v Watford
Gameweek 4 - 11/09/2021 - Crystal Palace v Tottenham Hotspur
Gameweek 5 - 18/09/2021 - Tottenham Hotspur v Chelsea
Gameweek 6 - 25/09/2021 - Arsenal v Tottenham Hotspur
Gameweek 7 - 02/10/2021 - Tottenham Hotspur v Aston Villa
Gameweek 8 - 16/10/2021 - Newcastle United v Tottenham Hotspur
Gameweek 9 - 23/10/2021 - West Ham United v Tottenham Hotspur
Gameweek 10 - 30/10/2021 - Tottenham Hotspur v Manchester United
Gameweek 11 - 06/11/2021 - Everton v Tottenham Hotspur
Gameweek 12 - 20/11/2021 - Tottenham Hotspur v Leeds United
Gameweek 13 - 27/11/2021 - Burnley v Tottenham Hotspur
Gameweek 14 - 01/12/2021 - Tottenham Hotspur v Brentford
Gameweek 15 - 04/12/2021 - Tottenham Hotspur v Norwich City
Gameweek 16 - 11/12/2021 - Brighton v Tottenham Hotspur
Gameweek 17 -14/12/2021 - Leicester City v Tottenham Hotspur
Gameweek 18 - 18/12/2021 - Tottenham Hotspur v Liverpool
Gameweek 19 - 26/12/2021 - Tottenham Hotspur v Crystal Palace
Gameweek 20 - 28/12/2021 - Southampton v Tottenham Hotspur
Gameweek 21 - 01/01/2022 - Watford v Tottenham Hotspur
Gameweek 22 - 15/01/2022 - Tottenham Hotspur v Arsenal
Gameweek 23 - 22/01/2022 - Chelsea v Tottenham Hotspur
Gameweek 24 - 09/02/2022 - Tottenham Hotspur v Southampton
Gameweek 25 - 12/02/2022 - Tottenham Hotspur v Wolverhampton
Gameweek 26 - 19/02/2022 - Manchester City v Tottenham Hotspur
Gameweek 27 - 26/02/2022 - Leeds United v Tottenham Hotspur
Gameweek 28 - 05/03/2022 - Tottenham Hotspur v Everton
Gameweek 29 - 12/03/2022 - Manchester United v Tottenham Hotspur
Gameweek 30 - 19/03/2022 - Tottenham Hotspur v West Ham United
Gameweek 31 - 02/04/2022 - Tottenham Hotspur v Newcastle United
Gameweek 32 - 09/04/2022 - Aston Villa v Tottenham Hotspur
Gameweek 33 - 16/04/2022 - Tottenham Hotspur v Brighton
Gameweek 34 - 23/04/2022 - Brentford v Tottenham Hotspur
Gameweek 35 - 30/04/2022 - Tottenham Hotspur v Leicester City
Gameweek 36 - 07/05/2022 - Liverpool v Tottenham Hotspur
Gameweek 37 - 15/05/2022 - Tottenham Hotspur v Burnley
Gameweek 38 - 22/05/2022 (16:00) - Norwich City v Tottenham Hotspur
Source: 90min
